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Normal neurulation in mammals

G Morriss-Kay1, H Wood, W H Chen

  • 1Department of Human Anatomy, University of Oxford, UK.

Ciba Foundation Symposium
|January 1, 1994
PubMed
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Mammalian neurulation exhibits regional differences in cranial, trunk, and caudal regions, impacting morphogenesis and gene expression. Retinoic acid levels are crucial for normal rhombomere development and region-specific gene patterns during neurulation.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Mammalian neurulation involves complex regional differences in cranial, trunk, and caudal regions.
  • These regions display distinct patterns of morphogenesis and gene expression during development.
  • Cranial neurulation is particularly complex, with hindbrain segmentation into rhombomeres.

Purpose of the Study:

  • To investigate the regional differences in mammalian neurulation.
  • To explore the role of retinoic acid in regional gene expression and morphogenesis.
  • To understand the mechanism of region-specific gene expression during neurulation.

Main Methods:

  • Comparative analysis of regional morphogenesis during neurulation.
  • Examination of gene expression patterns in cranial, trunk, and caudal neuroepithelium.

Related Experiment Videos

  • Analysis of retinoic acid receptors and retinoid binding proteins expression.

    • Main Results:

    • Distinct regional patterns of morphogenesis and gene expression were observed during mammalian neurulation.
    • Low retinoic acid levels are essential for normal rhombomere formation and gene expression.
    • Regional expression patterns of retinoic acid receptors and binding proteins suggest a regulatory role.

    Conclusions:

    • Regional differences in mammalian neurulation are characterized by specific morphogenetic and gene expression patterns.
    • Retinoic acid signaling plays a critical role in establishing region-specific gene expression and rhombomere development.
    • Understanding these patterns provides insight into the mechanisms of embryonic development.