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Normal neurulation in amphibians

A G Jacobson1

  • 1Department of Zoology, University of Texas at Austin 78712-1064.

Ciba Foundation Symposium
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Amphibian embryo neurulation involves neural plate cells changing shape, neighbors, and crawling. Actin filament contraction drives these cell behaviors to form the neural tube.

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Area of Science:

  • Developmental biology
  • Cell biology
  • Embryology

Background:

  • Neurulation is a critical process in early vertebrate development.
  • The amphibian neural plate undergoes significant shape transformations during neurulation.

Purpose of the Study:

  • To elucidate the cellular mechanisms driving amphibian embryo neurulation.
  • To identify the forces and cell behaviors responsible for neural tube formation.

Main Methods:

  • Experiments and observations of amphibian embryos.
  • Computer simulations of cell behavior during neurulation.
  • Analysis of cell shape changes, neighbor interactions, and cell movements.

Main Results:

  • Neural plate cells change shape, alter neighbor contacts, and migrate. Apical surface contraction contributes to thickening and rolling.

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  • Cellular repositioning along boundaries increases length and decreases width. Crawling beneath epidermis generates the primary folding force.
  • Poisson buckling may aid tube formation. Actin filament contraction is identified as the primary force generator.

    • Conclusions:

    • Neurulation is accomplished through coordinated cell behaviors including shape change, neighbor dynamics, and directed migration.
    • Actin filament contraction is the principal force driving neural tube formation in amphibian embryos.
    • Understanding these cellular dynamics provides insight into fundamental developmental processes.