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Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
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Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
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Dysrhythmias II: Classification of Tachyarrhythmias01:28

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Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
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Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Adenosine-induced non-sustained polymorphic ventricular tachycardia

M Romer1, R Candinas

  • 1Department of Internal Medicine, University Hospital, Zürich, Switzerland.

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|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Adenosine effectively terminates supraventricular tachycardias by inducing temporary heart block. However, this case highlights a rare risk of developing ventricular tachycardia after adenosine administration.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Adenosine is a widely used diagnostic and therapeutic agent for managing arrhythmias, particularly supraventricular tachycardias.
  • Its mechanism involves transient atrioventricular nodal block, effectively terminating reentrant tachycardias involving the AV node.

Observation:

  • A 56-year-old woman presented with supraventricular tachycardia.
  • Intravenous adenosine was administered to restore normal sinus rhythm.

Findings:

  • Adenosine successfully terminated the supraventricular tachycardia.
  • Following the termination, the patient experienced a brief episode of non-sustained polymorphic ventricular tachycardia.

Implications:

  • While adenosine is generally considered safe due to its short half-life and limited adverse effects, this case underscores a potential, albeit rare, risk of inducing ventricular arrhythmias.
  • Clinicians should remain vigilant for unexpected cardiac events, including ventricular tachycardia, even with the use of adenosine for supraventricular tachycardia treatment.