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Skeletal maturity in myelodysplasia
1University of Florida College of Medicine, JHM Health Center, Gainesville 32610.
Developmental Medicine and Child Neurology
|June 1, 1994
Summary
Many myelomeningocele patients show advanced bone age, particularly those over eight years old. This skeletal immaturity assessment used hand and wrist X-rays, finding no correlation with common patient factors.
Area of Science:
- Pediatric orthopedics
- Developmental biology
Background:
- Myelomeningocele is a complex congenital condition affecting skeletal development.
- Assessing skeletal maturity is crucial for managing growth and orthopedic interventions.
Purpose of the Study:
- To evaluate skeletal age incongruence in myelomeningocele patients.
- To determine the prevalence of advanced bone age in this population.
Main Methods:
- Retrospective analysis of 76 myelomeningocele patients.
- Single hand and wrist radiograph for bone age assessment.
- Comparison of bone age to chronological age, with a threshold of >2 standard deviations for incongruence.
Main Results:
- 28% of patients exhibited bone age more than two standard deviations from chronological age.
- 22% of patients demonstrated advanced skeletal age.
- Skeletal advancement was significantly higher in patients over eight years old (32%) compared to those younger (11%).
- No significant correlation was found between advanced bone age and gender, neurological level, hydrocephalus, or shunt revision history.
Conclusions:
- A notable proportion of myelomeningocele patients present with advanced skeletal age, especially older children.
- Bone age assessment is a relevant tool for monitoring skeletal development in myelomeningocele.
- Further research is needed to understand the underlying mechanisms and clinical implications of skeletal age incongruence in myelomeningocele.