Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Red cell deformability in gestational hypertension

L Heilmann1, B Hojnacki, G F von Tempelhoff

  • 1Department of Obstetrics and Gynecology, City Hospital Rüsselsheim, FRG.

Gynecologic and Obstetric Investigation
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Features of Polycystic Ovary Syndrome in adolescence.

Journal of medicine and life·2015
Same author

Histone and ribosomal RNA repetitive gene clusters of the boll weevil are linked in a tandem array.

Insect molecular biology·2010
Same author

The rheological changes after cesarean section: The influence of low molecular weight or unfractionated heparin on the rheological properties of blood.

Clinical hemorheology and microcirculation·2007
Same author

Successful treatment of life-threatening bleeding after cesarean section with recombinant activated factor VII.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2006
Same author

[Influence of thrombophilia in women with recurrent miscarriage: pros and cons].

Hamostaseologie·2006
Same author

Fetal hemorheology in normal pregnancy and severe preeclampsia.

Clinical hemorheology and microcirculation·2005

Red blood cell deformability is reduced in women with gestational hypertension, impacting newborn weight. This finding highlights the importance of erythrocyte function in pregnancy complications.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Physiology

Background:

  • Gestational hypertension is a common pregnancy complication.
  • Erythrocyte (red blood cell) deformability is crucial for microcirculation.
  • Changes in red blood cell characteristics may occur during pregnancy.

Purpose of the Study:

  • To investigate erythrocyte deformability in women with gestational hypertension.
  • To compare red blood cell characteristics between gestational hypertension, normal pregnancy, and nonpregnant states.
  • To explore correlations between red cell filterability and newborn weight.

Main Methods:

  • Studied erythrocyte deformability and red cell indices (MCV, MCHC, Hct).
  • Assessed 18 patients with gestational hypertension, 24 normotensive primigravidae, and 20 nonpregnant controls.

Related Experiment Videos

  • Measured red cell filtration using a filtrometer MF4 after cotton wool prefiltration.

    • Main Results:

    • Significantly reduced erythrocyte deformability was observed in patients with gestational hypertension compared to controls.
    • A strong positive correlation was found between red cell filterability and newborn weight (r = 0.59, p < 0.02).
    • Erythrocyte deformability in gestational hypertension is influenced by cell membrane fluidity, hemoglobin viscosity, and surface area/volume ratio.

    Conclusions:

    • Gestational hypertension is associated with impaired red blood cell deformability.
    • Reduced red cell filterability may be linked to adverse newborn outcomes, such as lower birth weight.
    • Cellular factors like membrane fluidity are key determinants of erythrocyte deformability in this condition.