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Growth temperature reversibly modulates the virulence of Legionella pneumophila
W S Mauchline1, B W James, R B Fitzgeorge
1Division of Pathology, Public Health Laboratory Service Centre for Applied Microbiology & Research, Porton Down, Salisbury, Wiltshire, United Kingdom.
Infection and Immunity
|July 1, 1994
Abstract:
In chemostat culture, the virulence of two strains of Legionella pneumophila was shown to be significantly (P < 0.05) reduced when the culture temperature was lowered from 37 to 24 degrees C. This modulation was reversed by returning the temperature to 37 degrees C, which resulted in a statistically significant (P < 0.05) increase in virulence.