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Sympathetic nerve activity during prolonged rhythmic forearm exercise

B A Batman1, J C Hardy, U A Leuenberger

  • 1Division of Cardiology/Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 1, 1994
PubMed
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Prolonged rhythmic exercise increases muscle sympathetic nerve activity (MSNA) but not through metaboreceptor stimulation. Static exercise, however, activates metaboreceptors and causes muscle acidosis, unlike rhythmic exercise.

Area of Science:

  • Exercise Physiology
  • Autonomic Nervous System Regulation
  • Muscle Metabolism

Background:

  • Exercise activates the sympathetic nervous system, influencing muscle sympathetic nerve activity (MSNA).
  • Metabolite-sensitive muscle afferents are thought to trigger MSNA responses, particularly near fatigue during isometric exercise.
  • Prolonged rhythmic exercise may activate the sympathetic nervous system differently than static exercise.

Purpose of the Study:

  • To investigate if metaboreceptor stimulation contributes to MSNA responses during prolonged rhythmic isotonic forearm exercise.
  • To compare MSNA and muscle metabolic responses between rhythmic and static forearm exercise paradigms.

Main Methods:

  • Subjects performed 30 minutes of rhythmic isotonic forearm exercise at 25% maximal voluntary contraction, with MSNA measured via microneurography.

Related Experiment Videos

  • Post-handgrip circulatory arrest (PHG-CA) was used to isolate metaboreceptor contribution to MSNA.
  • 31P-nuclear magnetic resonance spectroscopy evaluated muscle metabolic changes during both exercise types.

    • Main Results:

    • Rhythmic exercise induced progressive increases in MSNA, peaking at 161 units above baseline.
    • PHG-CA did not reveal a significant metaboreceptor contribution to MSNA during rhythmic exercise recovery.
    • Static exercise, unlike rhythmic exercise, induced muscle acidosis and H2PO4- accumulation and showed a sustained MSNA response during PHG-CA.

    Conclusions:

    • Metaboreceptor stimulation is not the primary driver of MSNA during prolonged rhythmic isotonic forearm exercise.
    • Static exercise engages metaboreceptors and alters muscle metabolism, leading to sustained MSNA, which differs from the response to rhythmic exercise.