Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monospermic polyploidy and atypical embryo morphology

S Munné1, M Alikani, J Cohen

  • 1Department of Obstetrics and Gynecology, New York Hospital--Cornell University Medical Center, NY 10021.

Human Reproduction (Oxford, England)
|March 1, 1994
PubMed
Summary

Rare genetic abnormalities in human embryos were identified. Monospermic polyploid embryos showed unique morphological features, distinct from polyspermic embryos, aiding in understanding early human development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AIDS vaccines: is older better?

Science (New York, N.Y.)·1992
Same author

AIDS vaccines. Trials set in high-risk populations.

Science (New York, N.Y.)·1992
Same author

Dingell rips Healy for 'obstructionism'.

Science (New York, N.Y.)·1992
Same author

Meningococcal septicaemia in a C6-deficient patient and effects of plasma transfusion on lipopolysaccharide release.

Lancet (London, England)·1992
Same author

Pediatric AIDS vaccine trials set.

Science (New York, N.Y.)·1992
Same author

A comparative study of imipenem versus piperacillin plus gentamicin in the initial management of febrile neutropenic patients with haematological malignancies.

The Journal of antimicrobial chemotherapy·1992

Area of Science:

  • Reproductive biology
  • Human embryology
  • Genetics

Background:

  • Polyploidy in human embryos can arise from various fertilization events.
  • Understanding the morphological characteristics of polyploid embryos is crucial for developmental studies.

Purpose of the Study:

  • To investigate the morphological and genetic characteristics of monospermic polyploid human embryos.
  • To differentiate between distinct types of monospermic polyploidy based on morphology and genetic makeup.

Main Methods:

  • Analysis of cleavage-arrested human embryos.
  • Fluorescence in-situ hybridization (FISH) using DNA probes for chromosomes X, Y, and 18.

Main Results:

  • Two distinct groups of monospermic polyploid embryos were identified.

Related Experiment Videos

  • Group (i) consisted of embryos with a single large cell and extracellular fragments, frequently exhibiting polyploid mosaicism.
  • Group (ii) comprised triploid or triploid mosaic embryos originating from larger-than-normal oocytes.

    • Conclusions:

    • Atypical morphologies in monospermic polyploid embryos are rare but genetically uniform.
    • These findings highlight a unique dual genetic-morphological abnormality, distinct from polyspermic embryos.