Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholinergic innervation of mouse forebrain structures

C A Kitt1, C Höhmann, J T Coyle

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196.

The Journal of Comparative Neurology
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Curing cancer and protecting the heart : Challenges in cardio-oncology in the era of modern tumor treatment].

Herz·2019
Same author

[Are the initial pH and the lactate values after cardiopulmonary resuscitation always crucial?]

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2018
Same author

Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis.

Clinical and translational allergy·2017
Same author

The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL.

Allergy·2017
Same author

The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children.

The European respiratory journal·2016
Same author

Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster.

Allergy·2015
Same journal

Inner Ear Anatomy of Caenagnathidae (Theropoda: Oviraptorosauria) Emphasizes Mosaic Evolution of the Avian Neurosensory System.

The Journal of comparative neurology·2026
Same journal

Inhibitory Neurons in Human Anterior Entorhinal Cortex and Some Comparisons With the Rhesus Monkey.

The Journal of comparative neurology·2026
Same journal

In Situ Hybridization Chain Reaction and Immunohistochemical Labeling of the Octopamine Production Pathway in the Central Nervous System of Lymnaea stagnalis.

The Journal of comparative neurology·2026
Same journal

Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.

The Journal of comparative neurology·2026
Same journal

Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula.

The Journal of comparative neurology·2026
Same journal

Proline-Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits.

The Journal of comparative neurology·2026
See all related articles

This study maps cholinergic innervation in the mouse brain, revealing distinct patterns in the cortex, hippocampus, amygdala, and thalamus. These findings establish a baseline for future research on cholinergic systems.

Area of Science:

  • Neuroscience
  • Neuroanatomy

Background:

  • Cholinergic systems are crucial for cognitive functions.
  • Understanding the distribution of cholinergic innervation is essential for studying neurological disorders and treatments.

Purpose of the Study:

  • To investigate regional and laminar differences in cholinergic innervation in the mouse forebrain.
  • To provide a detailed map of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) distribution.
  • To establish a baseline for future studies on the effects of transgenes and age on these systems.

Main Methods:

  • Choline acetyltransferase (ChAT) immunocytochemistry was used.
  • Acetylcholinesterase (AChE) histochemistry was employed.
  • Analysis was conducted across the cerebral cortex, hippocampus, amygdala, and thalamus of mice.

Related Experiment Videos

Main Results:

  • Mouse cortical cholinergic innervation exhibits a trilaminar pattern, distinct from rats, with prominent fibers in specific layers.
  • The basolateral nucleus of the amygdala showed the highest density of cholinergic processes.
  • Specific regions within the hippocampus and thalamus displayed high densities of cholinergic innervation.

Conclusions:

  • The study provides a detailed map of cholinergic innervation in the mouse forebrain.
  • Identified regional and laminar differences offer insights into the functional organization of these systems.
  • The findings serve as a foundation for investigating age-related changes and genetic modifications in the brain's cholinergic system.