Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemispheric processing and methylphenidate effects in attention-deficit hyperactivity disorder

M A Malone1, J R Kershner, J M Swanson

  • 1Division of Neurology, Hospital For Sick Children, Toronto, Ontario, Canada.

Journal of Child Neurology
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A risk calculator to predict adult attention-deficit/hyperactivity disorder: generation and external validation in three birth cohorts and one clinical sample - ERRATUM.

Epidemiology and psychiatric sciences·2019
Same author

A risk calculator to predict adult attention-deficit/hyperactivity disorder: generation and external validation in three birth cohorts and one clinical sample.

Epidemiology and psychiatric sciences·2019
Same author

First Report of Verticillium Wilt Caused by Verticillium nonalfalfae on Tree-of-Heaven (Ailanthus altissima) in Ohio.

Plant disease·2019
Same author

The impact of an intensive multisensory reading program on a population of learning-disabled delinquents.

Annals of dyslexia·2013
Same author

Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease.

Molecular psychiatry·2012
Same author

Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway.

Molecular psychiatry·2010
Same journal

Birmingham, 1963.

Journal of child neurology·2026
Same journal

Hyperintensity on Diffusion-Weighted Imaging in a MELAS Patient Does Not Necessarily Mean Cytotoxic Edema.

Journal of child neurology·2026
Same journal

Neuromuscular Symptoms of <i>ORAI1</i>-Related Immunodeficiency.

Journal of child neurology·2026
Same journal

Symptoms of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, and Autism Spectrum Disorder in Children and Adolescents Attending a Headache Outpatient Clinic and School-Based Controls.

Journal of child neurology·2026
Same journal

Acute Encephalopathy From Central Nervous System Hemophagocytic Lymphohistiocytosis (CNS HLH) in X-Linked Lymphoproliferative Disease Type 1 (XLP-1).

Journal of child neurology·2026
Same journal

The Cost of Fear for Pediatric Neurologic Care.

Journal of child neurology·2026
See all related articles

Attention-deficit hyperactivity disorder (ADHD) may stem from neurotransmitter imbalances and bihemispheric dysfunction. ADHD medications may help by restoring neurotransmitter balance and improving attentional resource allocation between brain hemispheres.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurochemistry

Background:

  • Attention-deficit hyperactivity disorder (ADHD) is associated with neurotransmitter imbalances.
  • An asymmetric neural control system links dopaminergic pathways to left-hemispheric and noradrenergic pathways to right-hemispheric processing.

Purpose of the Study:

  • To explore the roles of norepinephrine and dopamine imbalances in ADHD.
  • To investigate the link between hemispheric processing and ADHD pathophysiology.
  • To understand the mechanism of action for ADHD medications.

Main Methods:

  • Review of existing evidence on neurotransmitter systems in ADHD.
  • Analysis of the asymmetric neural control system model.
  • Hypothesizing medication effects based on neurochemical and hemispheric interactions.

Related Experiment Videos

Main Results:

  • ADHD may involve bihemispheric dysfunction with reduced dopaminergic and excessive noradrenergic functioning.
  • Medication effects may be linked to restoring neurotransmitter balance.
  • Medications may enhance control over attentional resource allocation between hemispheres.

Conclusions:

  • ADHD pathophysiology may involve a complex interplay of neurotransmitter imbalances and hemispheric dysfunction.
  • Medication efficacy in ADHD may be explained by the restoration of neurochemical balance and improved interhemispheric attentional control.