Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Brain repair

¹University of Cambridge Neurology Unit, Addenbrooke's Hospital.

Journal of the Royal College of Physicians of London

|March 1, 1994

Summary

This summary is machine-generated.

The adult central nervous system (CNS) does not repair itself, leading to progressive brain and spinal cord diseases. Emerging strategies focus on enhancing regeneration and limiting damage for potential clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acting on incidental findings in research imaging.

BMJ (Clinical research ed.)·2015

Same author

Exome sequencing in single cells from the cerebrospinal fluid in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2014

Same author

Genetic burden in multiple sclerosis families.

Genes and immunity·2013

Same author

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.

Nature protocols·2011

Same author

Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.

Cell death and differentiation·2011

Same author

Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.

Genes and immunity·2010

Same journal

A Change of Government and Its Effect on the NHS Hospital Outpatient Service.

Journal of the Royal College of Physicians of London·2019

Same journal

Erratum: Model for the Organisation of a Community-Based Rehabilitation Service.

Journal of the Royal College of Physicians of London·2019

Same journal

Telemedicine and beyond.

Journal of the Royal College of Physicians of London·2019

Same journal

Palliative Care in General Medicine.

Journal of the Royal College of Physicians of London·2019

Same journal

Medical Negligence.

Journal of the Royal College of Physicians of London·2019

Same journal

In Response.

Journal of the Royal College of Physicians of London·2019

See all related articles

Area of Science:

Neuroscience
Regenerative Medicine
Neurology

Background:

Central nervous system (CNS) diseases are common and progressive due to limited self-repair capacity in adult humans.
Unlike peripheral nerves, the adult human CNS lacks spontaneous regeneration, contributing to disease progression.

Purpose of the Study:

To elucidate the scientific basis for the lack of CNS regeneration.
To identify strategies for enhancing CNS repair and limiting neurodegeneration.
To explore cell implantation as a potential therapeutic approach.

Main Methods:

Investigating nervous system development and cell lineages.
Studying neurodegenerative processes to understand damage mechanisms.
Evaluating cell implantation techniques experimentally and clinically.

Related Experiment Videos

Main Results:

Studies have begun to reveal the scientific underpinnings of limited CNS regeneration.
Understanding neurodegeneration provides rationale for damage-limiting treatments.
Cell implantation shows promise for restoring CNS structure.

Conclusions:

A cohesive strategy for mitigating CNS damage and promoting repair is emerging.
Translating these research findings into clinical practice is anticipated.
Future therapeutic approaches may combine regenerative strategies with neuroprotective treatments.