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Related Experiment Videos

Acetic acid intoxication by rectal administration

M Kawamata1, S Fujita, T Mayumi

  • 1Department of Anesthesiology, Sapporo Medical University, School of Medicine, Japan.

Journal of Toxicology. Clinical Toxicology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Accidental rectal administration of concentrated acetic acid caused severe toxicity in a child. This case highlights the dangers of undiluted acid exposure in the lower gastrointestinal tract.

Area of Science:

  • Toxicology
  • Gastroenterology
  • Pediatrics

Background:

  • Rectal administration of substances bypasses upper gastrointestinal dilution and neutralization.
  • Concentrated acids pose significant risks when introduced directly into sensitive tissues.

Observation:

  • A 5-year-old boy experienced accidental rectal administration of 50 mL of 9% acetic acid.
  • The substance was not diluted or neutralized prior to reaching the colon.

Findings:

  • The patient developed severe complications including colon necrosis.
  • Acute renal failure, liver dysfunction, and disseminated intravascular coagulopathy (DIC) were observed.
  • Sepsis complicated the clinical presentation, indicating a systemic inflammatory response.

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Implications:

  • Direct rectal instillation of concentrated acetic acid can lead to life-threatening systemic toxicity.
  • This case underscores the critical importance of proper dilution and administration routes for all ingested or instilled substances.
  • Healthcare providers should be aware of the potential for severe local and systemic injury from rectal acid exposure.