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Medicinal applications of cyclodextrins

J Szejtli1

  • 1CYCLOLAB Cyclodextrin Research and Development Laboratory Ltd., Budapest, Hungary.

Medicinal Research Reviews
|May 1, 1994
PubMed
Summary

Cyclodextrins (CDs) enhance drug formulation by improving solubility, stability, and delivery across various routes. These versatile compounds offer solutions for challenging drug properties, leading to better therapeutic outcomes.

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Area of Science:

  • Pharmaceutical Sciences
  • Medicinal Chemistry
  • Drug Delivery Systems

Background:

  • Cyclodextrins (CDs) are industrially produced compounds available in pharmaceutical grades.
  • Their primary medicinal application involves complexing drugs with poor solubility, stability, or formulation issues.

Purpose of the Study:

  • To explore the multifaceted applications of cyclodextrins in pharmaceutical formulations.
  • To highlight how cyclodextrin complexation improves drug properties and administration routes.

Main Methods:

  • Review of existing literature on cyclodextrin applications in drug formulation.
  • Analysis of the impact of cyclodextrin complexation on drug physicochemical properties.
  • Examination of cyclodextrin utility across diverse dosage forms (oral, parenteral, transdermal, etc.).

Main Results:

  • CD complexation significantly enhances drug wettability, dissolution, solubility, and stability.
  • Improved bioavailability and absorption are observed, particularly in oral and parenteral formulations.
  • CDs enable novel administration routes like transdermal and nasal delivery for previously challenging drugs.

Conclusions:

  • Cyclodextrins are versatile excipients that address numerous drug formulation challenges.
  • Their use improves drug efficacy, safety, and patient compliance across various dosage forms.
  • Direct therapeutic roles and use as tableting vehicles are also demonstrated.

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