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Published on: August 10, 2012
Modulatory action of neurotensin on the pituitary-adrenocortical function in rats: evidence for an acute
L K Malendowicz1, G G Nussdorfer
1Department of Histology and Embriology, School of Medicine, Poznan, Poland.
Abstract:
Adult female rats were sc injected with 0.6 or 1.2 nmol/100 g body wt of neurotensin (NT); control animals received a sc injection of saline vehicle. The plasma concentrations of ACTH, aldosterone and corticosterone were measured 1, 2 or 4 h after the injection. Our RIA estimates revealed that the lower dose of NT exerted a net stimulatory effect on the rat pituitary-adrenocortical function, that can be ascribed to the well-known NT-evoked enhancement of CRH release. Conversely, the higher dose of NT appeared to have a marked inhibitory effect on both pituitary ACTH release and adrenocortical secretion. The mechanism underlying this last action of NT remains to be elucidated.
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