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Effect of metallothionein I on mitochondrial oxygen consumption
C O Simpkins1, H L Zhao, C A Torrence
1University of Maryland School of Medicine, Department of Surgery, Baltimore.
Life Sciences
|January 1, 1994
Abstract:
The effect of the stress-induced, cysteine-rich protein, metallothionein I (MT), on oxygen consumption by rat liver mitochondria was studied. Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT. The MT effect was concentration dependent. No evidence was found for the provision by MT of an alternate pathway to oxygen.