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Mixed oligoastrocytomas: a survival and prognostic factor analysis
E G Shaw1, B W Scheithauer, J R O'Fallon
1Division of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Neurosurgery
|April 1, 1994
Summary
For patients with supratentorial mixed oligoastrocytomas, tumor grade is the strongest predictor of survival. Lower tumor grades and specific treatments like radiation therapy significantly improve outcomes for these brain tumor patients.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiation Oncology
Background:
- Supratentorial mixed oligoastrocytomas are rare brain tumors.
- Treatment strategies have evolved, impacting patient prognosis.
Purpose of the Study:
- To identify prognostic factors for survival in patients with supratentorial mixed oligoastrocytomas.
- To evaluate the impact of tumor grade and treatment on patient outcomes.
Main Methods:
- Retrospective analysis of 71 patients treated between 1960 and 1982.
- Inclusion of surgery alone or surgery with postoperative radiation therapy.
- Uni- and multivariate survival analyses applied to 14 prognostic factors.
Main Results:
- Tumor grade (Kernohan method) was the most significant prognostic factor.
- Lower grades (1-2) had significantly better median survival (6.3 years) than higher grades (3-4) (2.8 years).
- Factors associated with improved survival included younger age (<37), gross total resection, partial brain radiation, and higher radiation doses (≥5000 cGy).
Conclusions:
- Tumor grade is a critical determinant of survival in supratentorial mixed oligoastrocytomas.
- Postoperative radiation therapy, extent of surgical resection, and patient age are important factors influencing outcomes.
- Anaplastic transformation was observed during tumor progression.