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Structure-activity relationships for relaxation of smooth muscle by VIP
H Shirahase1, D H Coy, O P Rorstad
1Department of Medicine, University of Calgary, Calgary General Hospital, Alberta, Canada.
Peptides
|January 1, 1994
Abstract:
Utilizing VIP and five VIP analogues, concentration-response curves for relaxation of rat mesenteric artery and rat gastric longitudinal muscle were determined for comparison with our previously published radioligand binding data on rat smooth muscle and other tissues. The biological potency of the VIP analogues in the present study compared more closely with their potency for VIP receptor binding in smooth muscle tissue (arteries) vs. other tissues (pituitary, brain, liver).