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Naked megakaryocyte nuclei in bone marrows of patients with acquired immunodeficiency syndrome: a somewhat specific
1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Abstract:
Naked megakaryocyte nuclei (NMN) were studied retrospectively in 100 bone marrow biopsy sections and aspirates from patients with acquired immunodeficiency syndrome (AIDS) and 124 non-AIDS controls. An NMN score was developed to semiquantitate the NMN. The AIDS bone marrows had an incidence of 97% and a mean NMN score of 2.24 which was a higher incidence and score than the control groups and was statistically significant. The control groups consisted of 20 chronic myeloproliferative disorders (incidence of 70% and score of 1.4); 24 cases of acute myelogenous leukemia and myelodysplastic syndrome (incidence of 29.2% and 0.46 score); 22 cases of non-AIDS immune thrombocytopenic purpura (incidence of 50% and 0.82 score); 11 cases of acute lymphocytic leukemia (0% incidence); 21 cases of anemia (52.4% incidence and 0.7 score); and 26 cases of lymphoma staging (35% incidence and 0.35 score). It is concluded that NMN are a very frequent and, with a high score, a specific finding in AIDS bone marrow examinations.
Insights
Naked megakaryocyte nuclei (NMN) are significantly more frequent in acquired immunodeficiency syndrome (AIDS) bone marrow. This study developed an NMN scoring system, finding higher incidence and scores in AIDS patients compared to controls.
Area of Science:
- Hematology
- Immunology
- Pathology
Background:
- Naked megakaryocyte nuclei (NMN) are abnormal findings in bone marrow.
- Acquired immunodeficiency syndrome (AIDS) affects various bodily systems, including hematopoiesis.
Purpose of the Study:
- To investigate the incidence and significance of NMN in patients with AIDS.
- To develop a quantitative scoring system for NMN in bone marrow examinations.
Main Methods:
- Retrospective analysis of 100 bone marrow biopsy sections and aspirates from AIDS patients.
- Comparison with 124 non-AIDS control bone marrow samples.
- Development of a semiquantitative NMN scoring system.
Main Results:
- AIDS bone marrow showed a 97% incidence of NMN with a mean NMN score of 2.24.
- These findings were statistically significantly higher than in all control groups.
- Control groups included various hematologic conditions, with lower NMN incidence and scores.
Conclusions:
- Naked megakaryocyte nuclei are a frequent and specific finding in bone marrow examinations of AIDS patients.
- The NMN score can aid in the diagnosis and understanding of bone marrow changes in AIDS.