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[Changes in the diastolic left ventricular function in primary antiphospholipid antibody syndrome]
N Coudray1, D De Zuttere, O Blétry
1Service de médecine interne, hôpital la Pitié, Paris.
La Revue De Medecine Interne
|January 1, 1993
Summary
Primary antiphospholipid syndrome (PAPS) patients show unique left ventricular (LV) relaxation abnormalities. These findings suggest a direct link between PAPS and impaired diastolic function, impacting cardiac health.
Area of Science:
- Cardiology
- Rheumatology
- Medical Imaging
Context:
- Systemic lupus erythematosus is known to affect cardiac function.
- Primary antiphospholipid syndrome (PAPS) is an autoimmune condition.
- Left ventricular (LV) diastolic dysfunction is a potential complication.
Purpose:
- To prospectively investigate LV diastolic function in PAPS patients.
- To compare echo-Doppler indices between PAPS patients and healthy controls.
- To identify potential causal links between PAPS and diastolic abnormalities.
Summary:
- Echo-Doppler assessment revealed previously undescribed LV relaxation abnormalities in PAPS patients.
- PAPS patients exhibited distinct diastolic function impairments compared to healthy controls.
- The observed abnormalities suggest a direct relationship between PAPS and cardiac diastolic dysfunction.
Impact:
- Highlights potential cardiac involvement in PAPS beyond typical manifestations.
- Suggests a need for cardiac screening in PAPS patients.
- Provides new insights into the pathophysiology of cardiovascular complications in autoimmune diseases.