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Related Experiment Videos

Papaverine-induced mydriasis

L E Hendrix1, J E Dion, M E Jensen

  • 1Department of Radiology, University of Virginia Health Sciences Center, Charlottesville.

AJNR. American Journal of Neuroradiology
|April 1, 1994
PubMed
Summary
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Local intraarterial papaverine infusion can cause temporary ipsilateral pupillary dilatation in patients with subarachnoid hemorrhage. This side effect resolved upon discontinuing the papaverine infusion.

Area of Science:

  • Neurology
  • Ophthalmology
  • Vascular Surgery

Background:

  • Subarachnoid hemorrhage frequently causes cerebral vasospasm.
  • Intraarterial papaverine is used to treat symptomatic vasospasm.
  • Ocular complications of neurovascular treatments require careful monitoring.

Observation:

  • Five patients undergoing treatment for SAH-induced vasospasm developed ipsilateral pupillary dilatation.
  • The infusion catheter tip was consistently positioned near the ophthalmic artery ostium within the internal carotid artery.
  • Pupillary changes were transient and resolved after papaverine infusion cessation.

Findings:

  • Local intraarterial papaverine infusion can induce temporary, ipsilateral pupillary dilatation.
  • The proximity of the infusion catheter to the ophthalmic artery may be a contributing factor.

Related Experiment Videos

  • Papaverine's vasodilatory effects might extend to the ophthalmic artery, affecting pupillary function.

    • Implications:

    • Clinicians should be aware of potential pupillary side effects during papaverine infusions for SAH.
    • Monitoring pupillary response is important in patients receiving intraarterial papaverine.
    • Understanding this adverse event can refine treatment protocols and patient management strategies.