Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperthermia in psychostimulant overdose

C W Callaway1, R F Clark

  • 1Department of Emergency Medicine, University of California San Diego School of Medicine.

Annals of Emergency Medicine
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrauterine growth restriction combined with a maternal high-fat diet increased adiposity and serum corticosterone levels in adult rat offspring.

Journal of developmental origins of health and disease·2018
Same author

Extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest - to whom and when, that's the difficult question!

Acta anaesthesiologica Scandinavica·2017
Same author

Altered expression and chromatin structure of the hippocampal IGF1r gene is associated with impaired hippocampal function in the adult IUGR male rat.

Journal of developmental origins of health and disease·2014
Same author

Incidence of re-arrest and critical events during prolonged transport of post-cardiac arrest patients.

Resuscitation·2010
Same author

CMAJ covers.

Canadian Medical Association journal·2010
Same author

Risk assessment of isolated aripiprazole exposures and toxicities: a retrospective study.

Clinical toxicology (Philadelphia, Pa.)·2009

Hyperthermia is a dangerous, yet treatable, side effect of psychostimulant drug overdose. Emergency physicians should recognize and manage this critical metabolic derangement in poisoned patients.

Area of Science:

  • Toxicology
  • Emergency Medicine
  • Neuropharmacology

Background:

  • Psychostimulant drugs (e.g., amphetamines, cocaine) cause severe, potentially lethal effects.
  • While cardiovascular and seizure complications are well-studied, metabolic derangements like hyperthermia are less understood.
  • Hyperthermia is a frequent and potentially fatal outcome in severe psychostimulant poisonings.

Purpose of the Study:

  • To review the characteristics and management of hyperthermia in psychostimulant poisoning.
  • To highlight hyperthermia as a primary toxic effect, potentially independent of other symptoms.
  • To explore the neurobiological mechanisms and potential therapeutic strategies for psychostimulant-induced hyperthermia.

Main Methods:

  • Literature review of clinical reports and animal studies on psychostimulant toxicity.

Related Experiment Videos

  • Analysis of the role of hyperthermia in psychostimulant-induced mortality and morbidity.
  • Examination of the neurochemical pathways, particularly dopamine receptor activation, involved in hyperthermia.

    • Main Results:

    • Drug-induced hyperthermia can be lethal on its own in animal models.
    • Hyperthermia can lead to rhabdomyolysis and increased morbidity in non-lethal poisonings.
    • Psychostimulant-induced hyperthermia is a primary effect, potentially occurring without seizures or increased motor activity, mediated by central dopamine receptor activation.

    Conclusions:

    • Hyperthermia is a critical, potentially lethal, but treatable manifestation of severe psychostimulant poisoning.
    • Current management includes cooling, tranquilization after cardiovascular stabilization, and possibly mechanical ventilation.
    • Dopamine-blocking neuroleptic drugs may offer a novel therapeutic adjunct, warranting further investigation.