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The porcine mammary gland as a bioreactor for complex proteins
T Morcöl1, R M Akers, J L Johnson
1Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Annals of the New York Academy of Sciences
|May 2, 1994
Abstract:
The similar biological activity of rhPC and hPC indicates that porcine mammary gland can perform many of the processing reactions necessary for recombinant synthesis of complex human proteins and produce them at levels suitable for industrial bioreactor applications. The health of the transgenic pigs appeared unaffected by the expression of high levels of the heterologous protein. We suggest that one of the advantages of using the mammary gland as a bioreactor appears to be the high cell density relative to that of cell culture.