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Aminosulfonic acid buffer preserves myocardium during prolonged ischemia
1Department of Surgery, University of Colorado School of Medicine, Denver.
The Annals of Thoracic Surgery
|June 1, 1994
Summary
Maintaining myocardial acid-base balance during cardiac surgery ischemia is crucial. A novel aminosulfonic acid buffer effectively preserved heart function and minimized injury compared to sodium bicarbonate.
Area of Science:
- Cardiology
- Biochemistry
- Physiology
Background:
- Myocardial acidosis is a significant complication during cardiopulmonary bypass.
- Effective acid-base control is essential for preserving cardiac function during ischemia.
Purpose of the Study:
- To evaluate the efficacy of a novel aminosulfonic acid buffer in preventing myocardial acidosis during global ischemia.
- To compare the protective effects of this buffer against sodium bicarbonate in preserving myocardial function.
Main Methods:
- Two groups of dogs underwent 3 hours of global ischemia at 20°C with cardioplegic infusion.
- One group received a NaMOPS/HEPES buffer, while the other received NaHCO3.
- Intramyocardial pH, adenosine triphosphate (ATP) levels, and cardiac contractility (Dp/Dt) were monitored.
Main Results:
- The aminosulfonic acid buffer group maintained normal myocardial pH and ATP levels throughout ischemia.
- This group also demonstrated preserved cardiac contractility and compliance post-reperfusion.
- The NaHCO3 group experienced significant acidosis, declining ATP levels, and impaired cardiac function.
Conclusions:
- Control of myocardial acid-base equilibrium alone during global ischemia effectively preserves myocardial function.
- Aminosulfonic acid buffers offer a superior strategy for minimizing reperfusion injury in cardiac surgery.