Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiologic basis for operation on Zenker's diverticulum

M Migliore1, H Payne, K Jeyasingham

  • 1Department of Thoracic Surgery, Frenchay Hospital, Bristol, England.

The Annals of Thoracic Surgery
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A high-sensitivity, high-throughput newborn screening assay for congenital cytomegalovirus-is it time for universal screening in the United Kingdom?

Frontiers in pediatrics·2025
Same author

Sexual Dysfunction in Prostate Cancer Patients According to Disease Stage and Treatment Modality.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Modeling realistic synaptic inputs of CA1 hippocampal pyramidal neurons and interneurons via Adaptive Generalized Leaky Integrate-and-Fire models.

Mathematical biosciences·2024
Same author

Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047).

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Mathematical generation of data-driven hippocampal CA1 pyramidal neurons and interneurons copies via A-GLIF models for large-scale networks covering the experimental variability range.

Mathematical biosciences·2024
Same author

RADICALS-HD: Reflections before the Results are Known.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same journal

Does prior percutaneous coronary revascularization negatively affect the outcomes of subsequent coronary artery bypass grafting?

The Annals of thoracic surgery·2026
Same journal

Lymph Node Dissection and Chylothorax - Balancing Oncologic Benefit Against Morbidity.

The Annals of thoracic surgery·2026
Same journal

Preserved Antegrade Pulmonary Blood Flow in Bidirectional Glenn: Outcomes and Considerations for Staged Palliation.

The Annals of thoracic surgery·2026
Same journal

Domo Arigato, Mr. Roboto.

The Annals of thoracic surgery·2026
Same journal

Impact of High SUVmax on Recurrence by Resection Strategy in Stage IA Adenocarcinoma ≤2 cm.

The Annals of thoracic surgery·2026
Same journal

Preoperative Treatment for Stage II NSCLC Requires Multidimensional Consideration.

The Annals of thoracic surgery·2026
See all related articles

Zenker's diverticulum (ZD) may not stem solely from upper esophageal sphincter resistance. Swallowing mechanism analysis reveals distinct manometric features in ZD patients, guiding surgical decisions.

Area of Science:

  • Gastroenterology
  • Physiology

Background:

  • Zenker's diverticulum (ZD) traditionally linked to upper esophageal sphincter (UES) resistance.
  • Previous understanding suggested increased pharyngeal contraction as a consequence.

Purpose of the Study:

  • To investigate the pathophysiologic characteristics of the swallowing mechanism in Zenker's diverticulum (ZD).
  • To explore the role of manometric features in ZD development.

Main Methods:

  • Esophageal manometry using the station pull-through technique.
  • Comparison of 14 ZD patients with a healthy control group.

Main Results:

  • Higher mean pharyngeal contraction amplitude in ZD patients, but similar duration.
  • Lower resting tone but higher closing pressure and longer duration of the UES in ZD patients.

Related Experiment Videos

  • Sphincteroesophageal incoordination observed in 9 ZD patients; upper esophageal contraction amplitude and duration were higher.

    • Conclusions:

    • Swallowing abnormalities, particularly sphincteroesophageal incoordination, are present in Zenker's diverticulum (ZD).
    • Manometric evaluation is crucial for individualized surgical planning in ZD patients.