Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interictal responsiveness in therapy-resistant partial epilepsy

R Rogozea1, V Florea-Ciocoiu, D Haţegan

  • 1Institute of Neurology and Psychiatry, Bucharest, Romania.

Romanian Journal of Neurology and Psychiatry = Revue Roumaine De Neurologie Et Psychiatrie
|July 1, 1993
PubMed
Summary

Patients with therapy-resistant partial seizures (TRPS) exhibit heightened orienting reactions. Antiepileptic drug treatment can improve these responsiveness disturbances, particularly with sustained therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The therapy by ischemic stress induces a durable EEG synchronization in alpha frequency band.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1995
Same author

Amino acid content of the brain in rats focal penicillin induced epilepsy.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1995
Same author

Habituation of orienting reaction in therapy-resistant partial epilepsy.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1995
Same author

Increased susceptibility to audiogenic seizures following withdrawal of progesterone.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1994
Same author

The cerebral content of excitatory and inhibitory amino acids in rats following withdrawal of antiepileptic drugs.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1994
Same author

Diagnostic value of computerized EEG topographic analysis in epilepsy (preliminary data).

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1993

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Psychophysiology

Background:

  • Epilepsy, specifically therapy-resistant partial seizures (TRPS), is associated with altered nervous system excitability.
  • The orienting reaction (OR) reflects the brain's response to novel stimuli and can be a marker of nervous system function.

Purpose of the Study:

  • To investigate the somatic, autonomic, and electroencephalogram (EEG) components of the orienting reaction in individuals with TRPS.
  • To compare the OR in TRPS patients to healthy controls and epilepsy patients with controlled seizures.
  • To identify factors influencing responsiveness disturbances in TRPS.

Main Methods:

  • Polygraphic recordings of somatic, autonomic, and EEG activity during auditory-elicited orienting reactions.
  • Comparison of 66 TRPS patients with two control groups (135 subjects total).

Related Experiment Videos

  • Correlational and multivariate regression analyses to assess relationships between OR, clinical variables, and treatment parameters.

    • Main Results:

    • Epileptics with TRPS showed significantly heightened orienting reactions compared to both control groups.
    • Responsiveness disturbances were more pronounced in TRPS than in therapy-controlled epilepsy.
    • Pretrial seizure frequency, seizure type, antiepileptic drug (AED) daily dose, and serum AED levels were significant predictors of responsiveness disturbances.
    • Sustained antiepileptic treatment demonstrated an improvement in interictal responsiveness disturbances.

    Conclusions:

    • Individuals with TRPS exhibit interictal hyperresponsivity, likely due to nervous system excitability disturbances.
    • Antiepileptic treatment positively modulates these responsiveness disturbances, with greater improvement seen in more sustained therapies.
    • These findings suggest that OR components can serve as indicators of nervous system excitability in epilepsy and may be influenced by treatment efficacy.