Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bladder defense mechanism

S G Mulholland, C L Parsons, S H Shrom

    Transactions of the American Association of Genito-Urinary Surgeons
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ovariectomy in young prepubertal dairy heifers causes complete suppression of mammary progesterone receptors.

    Domestic animal endocrinology·2014
    Same author

    The prevalence and clinical significance of autoantibodies to plasminogen activator inhibitor 1 in systemic lupus erythematosus.

    Lupus·2003
    Same author

    Effects of different transition diets on dry matter intake, milk production, and milk composition in dairy cows.

    Journal of dairy science·2003
    Same author

    Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows.

    Animal reproduction science·2003
    Same author

    Evaluation of different energy feeding systems with production data from lactating dairy cows offered grass silage-based diets.

    Journal of dairy science·2003
    Same author

    Peritoneal involvement in stage II colon cancer.

    American journal of clinical pathology·2003

    The bladder lining has a protective mucopolysaccharide layer that prevents bacterial adherence. Disrupting this layer increases bacterial binding, but it naturally regenerates within 24 hours, restoring protection.

    Area of Science:

    • Urology
    • Microbiology
    • Biochemistry

    Background:

    • Urinary tract infections (UTIs) require microorganisms to adhere to the bladder lining (vesical mucosa).
    • The bladder possesses a natural defense mechanism against bacterial colonization.

    Purpose of the Study:

    • To investigate the nature of the bladder's self-protective mechanism against bacterial adherence.
    • To understand how this protective layer functions and its susceptibility to disruption.

    Main Methods:

    • Histochemical staining was used to identify the chemical composition of the protective substance.
    • Bacterial adherence assays were performed after experimental disruption of the protective layer using acid treatment.

    Main Results:

    Related Experiment Videos

  • The protective substance was identified as a mucopolysaccharide.
  • Acid treatment of the vesical mucosa significantly increased bacterial adherence (20-100 fold).
  • The protective layer regenerated within 24 hours, returning bacterial adherence to baseline levels, independent of microbial species or metabolic activity.

    • Conclusions:

    • The bladder mucosa is protected by a regenerating mucopolysaccharide layer.
    • This layer is crucial in preventing bacterial colonization and subsequent UTIs.
    • The protective mechanism is robust and can recover from chemical disruption.