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An electrochemical method for detection of nucleic acid hybridisation
J M Hall1, J Moore-Smith, J V Bannister
1Cranfield Biotechnology Centre, Cranfield University, Bedfordshire.
Biochemistry and Molecular Biology International
|January 1, 1994
Abstract:
Preliminary investigations on the detection of nucleic acid hybridisation by direct electrochemical techniques are described. Initial experiments were performed with calf thymus DNA, while as a model system, plasmid DNA (pEMBL) which can be prepared in single stranded forms from each of two original double stranded plasmids (+19 and -19) was used. Electrochemical analyses have been performed using mercury pool, glassy carbon and screen printed carbon working electrodes.