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Impaired spatial learning by vasoactive intestinal peptide in Morris water maze task in the rat
S Itoh1, A Takashima, T Morimoto
1Department of Physiology, Kyoto Prefectural University of Medicine, Japan.
Canadian Journal of Physiology and Pharmacology
|January 1, 1994
Abstract:
Intracerebroventricular administration of vasoactive intestinal peptide (VIP) disturbed the learning by rats of the location of a platform submerged in a water pool. When the platform was removed from the pool, VIP injection produced marked impairment of the ability to find a previously learned location in the pool. This spatial memory impairment caused by VIP was restored by peripheral pre-administration of cerulein.