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Complications of plasma-exchange
M Belloni1, A Alghisi, L Scremin
1Immunohematology Service and Blood Bank, Civil Hospital, Vicenza, Italy.
The International Journal of Artificial Organs
|December 1, 1993
Summary
Apheresis complications affect 40% of patients, with a 1/500 mortality rate. Careful patient evaluation and diligent staff are crucial for preventing adverse events during apheresis procedures.
Area of Science:
- Medical procedures
- Hematology
- Nephrology
Background:
- Apheresis complications impact a significant portion of patients, affecting 40% of those treated and 10-14% of procedures.
- The mortality rate associated with apheresis is approximately 1 in 500 treated patients.
- Certain patient populations, including those with TTP/HUS and GBS, face elevated risks.
Purpose of the Study:
- To analyze the incidence and contributing factors of complications in apheresis.
- To highlight patient groups at higher risk for apheresis-related adverse events.
- To emphasize the importance of preventative measures in apheresis therapy.
Main Methods:
- Review of apheresis procedure data.
- Analysis of complication rates and contributing factors.
- Identification of high-risk patient profiles.
Main Results:
- Apheresis complications affect 40% of patients and 10-14% of procedures.
- Mortality rate is 1/500 treated patients.
- Complex techniques, central catheters, plasma infusion, and underlying pathologies increase complication severity.
Conclusions:
- Apheresis is a relatively safe therapy when indications are carefully evaluated.
- Diligent personnel and meticulous patient assessment are essential for minimizing apheresis complications.
- Risk stratification for patients with TTP/HUS and GBS is critical for safe apheresis management.