[Changes in the intraoperative hormonal homeostasis following infusion of lactated Ringer's solution with high...

Changes in the concentrations of serum electrolytes and those of water and electrolyte regulating hormones were studied in mongrel dogs undergoing a sham operation (gastrectomy) under general anesthesia. Six dogs (L-group) were infused regular lactated Ringer's solution containing 1% glucose, and other six dogs (KL-group) were infused lactated Ringer's solution containing 1% glucose and potassium 10 mEq.l-1. The serum potassium concentration decreased significantly during the surgery in the L-group, but it remained unchanged in the KL-group. Blood sugar level increased during and after the surgery in the L-group. On the other hand, the blood sugar level changed in a similar way as that of the L-group during the surgery, but it decreased after the surgery in the KL-group. NEFA level also decreased after the surgery in the KL-group. Aldosterone secretion was increased after the surgery in the L-group. On the other hand, the aldosterone secretion increased during the surgery in the KL-group. The differences of the aldosterone secretion between the groups may be due to the direct influence of potassium on the adrenal cortex. Serum concentration of ADH increased in both groups during the surgery. In the L-group, it remained later, but it recovered toward the initial level after the surgery in the KL-group. The above data indicate that no peculiar change occurred in hormonal homeostasis of subjects receiving operations under general anesthesia following the infusion of lactated Ringer's solution with high potassium concentration.