[The pathomorphosis of opisthorchiasis]

Area of Science:

• Medical Parasitology
• Infectious Diseases
• Gastroenterology

Background:

• Opisthorchiasis, a parasitic disease, presents with varied clinical manifestations.
• Pathomorphism, changes in disease presentation, has been observed in infectious diseases over time.
• The interplay between parasitic infections and common bacterial pathogens like Helicobacter pylori is complex.

Purpose of the Study:

• To analyze the evolving clinical picture of opisthorchiasis.
• To investigate the phenomenon of pathomorphism in opisthorchiasis.
• To explore the role of Helicobacter pylori in gastroduodenal pathology among opisthorchiasis patients.

Main Methods:

• Literature review of opisthorchiasis cases.
• Analysis of the authors' own clinical findings.
• Evaluation of etiological and pathogenetic factors in gastroduodenal diseases.

Main Results:

• The clinical presentation of opisthorchiasis has significantly changed over recent decades.
• Pathomorphism in opisthorchiasis manifests as reduced invasion rates and altered acute forms (uninduced) or timely invasion clearance (induced).
• Helicobacter pylori is implicated in gastroduodenal pathology in opisthorchiasis patients, termed 'false pathomorphism'.

Conclusions:

• Opisthorchiasis exhibits significant pathomorphism, altering its clinical and epidemiological characteristics.
• Induced and uninduced pathomorphism influence invasion dynamics and disease severity.
• The co-occurrence of Helicobacter pylori and opisthorchiasis contributes to complex gastroduodenal pathologies.