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Loss of receptors for transforming growth factor beta in human T-cell malignancies

M E Kadin1, M W Cavaille-Coll, R Gertz

  • 1Department of Pathology, Beth Israel Hospital, Boston, MA 02215.

Proceedings of the National Academy of Sciences of the United States of America
|June 21, 1994
PubMed

Insights

Tumor progression in Ki-1 (CD30)+ cutaneous T-cell lymphomas (CTCLs) is linked to a loss of transforming growth factor-beta (TGF-beta) receptors. Advanced CTCL cells lose TGF-beta receptor expression, contributing to tumor growth.

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Ki-1 (CD30)+ cutaneous T-cell lymphomas (CTCLs) are characterized by slow progression and spontaneous regression.
  • Understanding the mechanisms behind regression and progression is crucial for developing effective treatments.

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