Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth hormone receptor/binding protein: physiology and function

A C Herington1, S I Ymer, J L Stevenson

  • 1Centre for Child Growth and Hormone Research, Royal Children's Hospital, Melbourne, Australia.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|July 1, 1994
PubMed
Summary

Soluble growth hormone-binding proteins (GHBP) exist in circulation and tissues. Their interaction with growth hormone (GH) influences GH signaling pathways and biological effects, raising new research questions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An investigation into the impact of nine catchment characteristics on the accuracy of two phosphorus load apportionment models.

Environmental monitoring and assessment·2021
Same author

Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth.

Placenta·2016
Same author

Differentiating the bipolar disorders from borderline personality disorder.

Acta psychiatrica Scandinavica·2015
Same author

Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence.

The journal of nutrition, health & aging·2015
Same author

Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer.

Experimental cell research·2015
Same author

Inhibiting Eph kinase activity may not be "Eph"ective for cancer treatment.

Growth factors (Chur, Switzerland)·2014

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Signaling

Background:

  • Soluble truncated forms of the growth hormone receptor (GHR), known as growth hormone-binding proteins (GHBP), are found in circulation and produced by various tissues.
  • These GHBP are generated through alternative splicing in rodents and likely proteolytic cleavage in other species.
  • The precise origins, native forms, physiology, and functions of GHBP remain areas of active investigation.

Purpose of the Study:

  • To review current understanding of GHBP, focusing on their origins, molecular forms, and physiological roles.
  • To explore the implications of GHBP-GH interactions on growth hormone (GH) bioactivity and downstream signaling.
  • To highlight emerging questions and areas for future research based on recent advances in GHR structure, function, and signaling.

Related Experiment Videos

Main Methods:

  • Literature review and synthesis of existing research on GHR and GHBP.
  • Analysis of findings related to GH-induced dimerization of soluble GHBP and membrane GHR.
  • Discussion of implications for GH signal transduction pathways.

Main Results:

  • GHBP are present in circulation and tissues, with distinct production mechanisms across species.
  • GH induces dimerization of both soluble GHBP and membrane GHR.
  • GHBP-GH complex formation influences GH presentation to target cells, impacting receptor activation.

Conclusions:

  • The interaction between GH and GHBP, including monomeric or dimeric complexes, significantly affects GH's ability to activate postreceptor signaling pathways.
  • Understanding GHBP is crucial for deciphering the complex mechanisms of GH action.
  • Further research is needed to fully elucidate the structure, function, and physiological significance of GHBP in GH signaling.