Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumor-localizing fluorescent diagnostic agents without phototoxicity

T Takemura1, S Nakajima, I Sakata

  • 1Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan.

Photochemistry and Photobiology
|March 1, 1994
PubMed
Summary

Researchers developed novel tumor-localizing fluorescent diagnostic agents. These agents, linked heterodimers, aim to improve tumor detection without causing phototoxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of termination of postprandial gastric contractions in humans, dogs and Suncus murinus: role of motilin- and ghrelin-induced strong contraction.

Acta physiologica (Oxford, England)·2017
Same author

Time-Reversal Measurement of the p-Wave Cross Sections of the ^{7}Be(n,α)^{4}He Reaction for the Cosmological Li Problem.

Physical review letters·2017
Same author

Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1.

Molecular psychiatry·2016
Same author

Rikkunshito induces gastric relaxation via the β-adrenergic pathway in Suncus murinus.

Neurogastroenterology and motility·2015
Same author

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model.

Neuroscience·2015
Same author

Myenteric neural network activated by motilin in the stomach of Suncus murinus (house musk shrew).

Neurogastroenterology and motility·2011

Area of Science:

  • Medicinal Chemistry
  • Biomedical Imaging
  • Organic Synthesis

Background:

  • Phototoxicity remains a challenge for current fluorescent diagnostic agents.
  • Developing agents that specifically target tumors is crucial for early cancer detection.

Purpose of the Study:

  • To synthesize novel heterodimeric fluorescent diagnostic agents.
  • To create agents that localize to tumors and exhibit minimal phototoxicity.

Main Methods:

  • Synthesis of various heterodimers by linking chlorine derivatives with Mn or Cu complexes via spacers.
  • Characterization of the synthesized compounds, including HAT-DO1.

Main Results:

  • Successful synthesis of several heterodimeric compounds.

Related Experiment Videos

  • Identification of HAT-DO1 as a representative tumor-localizing agent.

    • Conclusions:

    • The synthesized heterodimers show potential as tumor-localizing fluorescent diagnostic agents.
    • HAT-DO1 represents a promising candidate for phototoxicity-free tumor imaging.