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[Effect of propofol on oxygenation and the pulmonary short-circuit during single-lung ventilation]
J A Pueyo1, A Pajuelo, R Fuentes
1Servicio de Anestesiología y Reanimación, Hospital Puerta del Mar, SAS, Cádiz.
Objectives:
To determine the effect of propofol on pulmonary short circuit or shunt (Qs/Qt).
Patients And Methods:
Nine patients undergoing scheduled thoracic surgery with single lung ventilation were studied. All patients were anesthesized with 2 mg/kg propofol followed by a continuous infusion of 4-6 mg/kg/h; fentanyl 0.3 mg followed by bolus as needed; and relaxed with atracurium 0.5 mg/kg followed by bolus of 0.1-0.2 mg/kg as needed. The ratio Qs/Qt was calculated with an FiO2 of 1 and patients in lateral decubitus.
Results:
During double-lung ventilation Qs/Qt was 17.4 +/- 5.4% and PO2 was 430 +/- 16 mmHg, while shunt increased to 27.8 +/- 8.4% and PO2 decreased to 258 +/- 127 mmHg during single-lung ventilation. Change was significant in both cases.
Conclusions:
Continuous infusion of propofol produces a significant increase of Qs/Qt and a significant decrease of PaO2 during single-lung ventilation for thoracic surgery.