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Leukotrien B4-induced interleukin-1 beta in synovial cells from patients with rheumatoid arthritis
Y Kageyama1, Y Koide, S Miyamoto
1Department of Orthopedics, Hamamatsu University School of Medicine, Japan.
Scandinavian Journal of Rheumatology
|January 1, 1994
Abstract:
We examined the role of Leukotrien B4 (LTB4) in the production of Interleukin-1 beta (IL-1 beta) by rheumatoid synovial cells since a substantial amount of LTB4 has been detected in the synovial fluid from patients with rheumatoid arthritis. The production of IL-1 beta was augmented by LTB4 at concentrations of 10(-9) to 10(-8) M. Furthermore, LTB4 showed the additive effect on the IL-1 beta production with interferon-gamma but not with lipopolysaccharide. These results suggest that LTB4 in cooperation with certain cytokines might play a pivotal role in the IL-1 beta production by rheumatoid synovial cells in vivo.