Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A physiologically based pharmacokinetic computer model for human pregnancy

R H Luecke1, W D Wosilait, B A Pearce

  • 1Department of Chemical Engineering, University of Missouri-Columbia 65211.

Teratology
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cloning, expression and functional characterization of prepared bovine, salmon, and cod basic fibroblast growth factor-2.

NPJ science of food·2025
Same author

Psychological factors influencing consumer intentions to consume cultured meat, fish and dairy.

Appetite·2024
Same author

The Longitudinal Association between Self-esteem and Depressive Symptoms in Adolescents: Separating between-person effects from within-person effects.

European journal of personality·2019
Same author

Associations among gait score, production data, abattoir registrations, and postmortem tibia measurements in broiler chickens.

Poultry science·2016
Same author

In vitro digestion of purified β-casein variants A(1), A(2), B, and I: effects on antioxidant and angiotensin-converting enzyme inhibitory capacity.

Journal of dairy science·2014
Same author

Validation of biomarkers for loin meat quality (M. longissimus) of pigs.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie·2014

This study developed a physiologically based pharmacokinetic (PBPK) model for human pregnancy, incorporating maternal and fetal changes. The model accurately simulates chemical concentrations in maternal and fetal organs throughout gestation.

Area of Science:

  • Pharmacokinetics
  • Physiology
  • Computational Biology

Background:

  • Physiologically based pharmacokinetic (PBPK) models for human pregnancy require specialized considerations for dynamic physiological changes.
  • Existing models often do not account for the significant alterations in the mother, placenta, and developing fetus during gestation.

Purpose of the Study:

  • To develop a comprehensive PBPK model for human pregnancy.
  • To accurately simulate the distribution and concentration of substances in maternal and fetal compartments throughout gestation.

Main Methods:

  • Utilized the Gompertz equation to model human embryo/fetal weight changes from 25 to 300 days of gestation.
  • Adapted allometric equations to correlate fetal organ weights, blood flow rates, and other parameters with total fetal weight.

Related Experiment Videos

  • Developed a PBPK model in FORTRAN 77 with 27 maternal and 16 fetal compartments, capable of simulating two substances.

    • Main Results:

    • The Gompertz equation provided a good fit for human embryo/fetal weight data.
    • Allometric relationships were successfully established for fetal organ weights and plasma flow rates.
    • The PBPK model, despite its complexity, can be solved efficiently on desktop computers and allows simulation of chemical concentrations in maternal and fetal organs.

    Conclusions:

    • The developed PBPK model effectively simulates physiological changes during human pregnancy.
    • The model's adaptability using allometric relationships allows for application to animal experimental data.
    • This computational tool aids in understanding chemical exposure and disposition in pregnant humans and animals.