Osmotic thirst suppression elicited by electrical stimulation of the basal forebrain in the dog

Reactivity of the thirst mechanism to osmotic stimuli was measured in conscious dogs chronically implanted with electrodes in the basal forebrain. It was found that the thirst threshold to the osmotic stimulus increases markedly during electrical stimulation of the preoptic area, septum, nucleus accumbens septi, and to smaller degree during stimulation of the nucleus caudatus. The possibility of existence of some inhibitory components in the neural system controlling thirst in the dog is suggested.