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Related Concept Videos

Ovaries01:26

Ovaries

The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of cuboidal...

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Related Experiment Video

Updated: May 13, 2026

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

Screening for ovarian cancer

K J Carlson1, S J Skates, D E Singer

  • 1Massachusetts General Hospital, Boston.

Annals of Internal Medicine
|July 15, 1994
PubMed
Summary

Screening asymptomatic women for ovarian cancer using ultrasound or CA 125 tests is not recommended. Current evidence shows high false-positive rates and no proven reduction in ovarian cancer mortality.

Area of Science:

  • Gynecologic oncology
  • Diagnostic test evaluation
  • Preventive medicine

Background:

  • Ovarian cancer remains a significant health concern.
  • Effective screening strategies are crucial for early detection and improved outcomes.

Purpose of the Study:

  • To critically review evidence on screening asymptomatic women for ovarian cancer.
  • Evaluate the utility of ultrasonography and CA 125 radioimmunoassay (CA 125) for ovarian cancer screening.

Main Methods:

  • Comprehensive literature search of MEDLINE and bibliographies.
  • Inclusion of observational studies, meta-analyses, randomized trials, and mathematical models.
  • Focus on ovarian cancer risk, test characteristics, treatment effectiveness, and mortality outcomes.

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Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
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A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
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A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions

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Last Updated: May 13, 2026

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
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Published on: March 3, 2023

Main Results:

  • Age and family history are key ovarian cancer risk factors.
  • Screening asymptomatic women over 50 without family history yields over 30 false positives per cancer detected.
  • No direct evidence shows screening reduces ovarian cancer mortality; false positives may lead to invasive procedures.

Conclusions:

  • Current evidence does not support screening women without a family history of ovarian cancer.
  • Routine screening is not advised for women with a family history unless a hereditary cancer syndrome is present.
  • Women with hereditary ovarian cancer syndromes require referral to a gynecologic oncologist.