Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics and multiple sclerosis: an overview

G C Ebers1

  • 1Multiple Sclerosis Clinic, University of Western Ontario, University Hospital, London, Canada.

Annals of Neurology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The relationship of age with the clinical phenotype in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2016
Same author

Review: the role of vitamin D in nervous system health and disease.

Neuropathology and applied neurobiology·2013
Same author

fMRI and corpus callosum relationships in monozygotic twins discordant for handedness.

Brain structure & function·2012
Same author

Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNβ-1b trial.

Neurology·2012
Same author

Age and disability accumulation in multiple sclerosis.

Neurology·2011
Same author

Relationship of UV exposure to prevalence of multiple sclerosis in England.

Neurology·2011
Same journal

Hyperacute Interleukin-1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion.

Annals of neurology·2026
Same journal

Gut-Brain Axis Modulation by Short-Chain Fatty Acids Exerts Disease-Modifying Effects in a Murine Model of Drug-Resistant Epilepsy.

Annals of neurology·2026
Same journal

From Marginal to Central: Marginal Zone-like B Cells as Critical Targets in Cladribine-Treated Multiple Sclerosis.

Annals of neurology·2026
Same journal

Comparable Infection Risk of Ocrelizumab and Rituximab in Multiple Sclerosis in a Nationwide Swedish Cohort Study.

Annals of neurology·2026
Same journal

Proinflammatory Epstein-Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis.

Annals of neurology·2026
Same journal

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing.

Annals of neurology·2026
See all related articles

Multiple sclerosis is a complex trait influenced by genetics and environment. Oligogenic models with epistatic interactions best explain genetic contributions, requiring large-scale genomic studies for confirmation.

Area of Science:

  • Genetics
  • Neuroimmunology
  • Complex Trait Genetics

Background:

  • Multiple sclerosis (MS) is understood as a complex trait with both genetic and environmental determinants.
  • Evidence includes higher concordance rates in monozygotic versus dizygotic twins and familial recurrence risks.
  • Existing data suggest genetic influences beyond simple Mendelian inheritance patterns.

Purpose of the Study:

  • To explore the genetic architecture of multiple sclerosis.
  • To evaluate the fit of current genetic data with various inheritance models.
  • To identify the necessity for advanced genetic screening techniques in MS research.

Main Methods:

  • Analysis of twin concordance data.
  • Evaluation of familial recurrence risk statistics.

Related Experiment Videos

  • Assessment of oligogenic hypotheses including epistatic interactions.

    • Main Results:

    • Genetic factors significantly contribute to multiple sclerosis etiology.
    • Oligogenic models, incorporating epistatic interactions, provide the best fit for observed genetic data.
    • Demonstrating the impact of specific genetic loci, like the Major Histocompatibility Complex, necessitates substantial family cohorts.

    Conclusions:

    • Multiple sclerosis genetics are complex, involving multiple genes with interactions.
    • Confirmation of oligogenic models requires comprehensive genome-wide linkage studies.
    • Large sample sizes are crucial for identifying specific genetic risk factors in MS.