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Rifampin-induced nonresponsiveness of giant cell arteritis to prednisone treatment
F Carrie1, P Roblot, S Bouquet
1Internal Medicine Service, University Hospital La Milétrie, Poitiers, France.
Archives of Internal Medicine
|July 11, 1994
Abstract:
Rifampin is an enzymatic inducer known to increase steroid metabolism. We studied two patients with giant cell arteritis in whom rifampin caused nonresponsiveness to prednisone treatment. A prednisone pharmacokinetics study was done. When rifampin-prednisone treatment must be used in giant cell arteritis, we propose increasing the prednisone dosage to 2 mg/kg per day.