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Fast neutron therapy. The UK experience

H M Warenius1

  • 1University of Liverpool, Department of Medicine, England.

Acta Oncologica (Stockholm, Sweden)
|January 1, 1994
PubMed
Summary
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This study on fast neutron therapy found a worse survival rate in patients treated with 62.5 MeV neutrons compared to conventional x-rays, leading to early termination. Further research into neutron therapy fractionation is recommended.

Area of Science:

  • Radiation Oncology
  • Medical Physics

Background:

  • Conflicting results existed regarding fast neutron therapy efficacy.
  • A 62.5 MeV (p-->Be+) Douglas cyclotron was installed for further studies.

Purpose of the Study:

  • To compare 62.5 MeV neutron therapy with conventional 8 MV x-ray therapy.
  • To achieve an unbiased comparison between the two treatment modalities.

Main Methods:

  • A pelvic study involving 151 patients was conducted.
  • Interim analysis was performed in autumn 1989.
  • Study design incorporated features for an unbiased comparison.

Main Results:

  • A trend towards worse survival in the neutron therapy group became significant.

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  • The study was terminated in February 1990 due to diminished survival.
  • No significant difference in morbidity was observed between groups.

    • Conclusions:

    • The reasons for diminished survival with neutron therapy were unclear.
    • Metastasis incidence did not fully explain the survival difference.
    • Consideration for smaller fractions in future neutron therapy at this energy is advised.