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Related Experiment Videos

Developmental expression of the RET protooncogene

V Avantaggiato1, N A Dathan, M Grieco

  • 1Istituto Internazionale di Genetica e Biofisica, Consiglio Nazionale delle Ricerche, Naples, Italy.

Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research
|March 1, 1994
PubMed
Summary

The RET protooncogene, implicated in thyroid cancer, is expressed during mouse development in neural structures, sensory organs, gut, kidney, and liver. This suggests RET

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The RET protooncogene encodes a receptor-type tyrosine kinase.
  • RET activation is primarily observed in human thyroid carcinomas.
  • Its role in normal development remains largely uncharacterized.

Purpose of the Study:

  • To investigate the expression pattern of the RET protooncogene during mouse embryogenesis.
  • To elucidate the potential developmental roles of RET.

Main Methods:

  • In situ hybridization on mouse embryos at various developmental stages.

Main Results:

  • RET expression was detected early in embryogenesis (around day 10).
  • Expression was observed in neural tube, encephalic ganglia, and neural crest derivatives.

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  • RET was also found in sensory organs (retina, olfactory epithelium), gut, developing kidney (metanephrogenic vesicles), and liver.
  • Specific expression in the ventral midbrain from 12.5 days postcoitum until birth was noted.

    • Conclusions:

    • RET exhibits a unique temporal and spatial expression pattern during mouse embryogenesis.
    • The findings suggest a potential role for RET in the differentiation of neural structures and the excretory system.