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Gastric ulcer in the elderly

¹Divisione di Geriatria, S.O. Schio, Italy.

The Italian Journal of Gastroenterology

|January 1, 1994

Summary

Gastric ulcer (GU) secretion patterns remain consistent with age. Elderly GU patients show increased glycoproteins and N-acetylneuraminic acid (NANA), while H2 blockers demonstrate high healing rates.

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Area of Science:

Gastroenterology
Geriatric Medicine
Oncology

Background:

Peptic ulcer disease, particularly gastric ulcers (GU), affects individuals across the age spectrum.
Limited understanding exists regarding age-related alterations in the gastric mucosal barrier.
Previous research indicates reduced prostaglandin levels in the gastric mucosa of elderly individuals.

Purpose of the Study:

To investigate age-related changes in gastric secretion and mucosal components in patients with peptic ulcers.
To compare secretory patterns between gastric ulcer (GU) and duodenal ulcer (DU) patients across different age groups.
To review the efficacy of H2 blockers in treating acute and maintaining chronic GU in the elderly.

Main Methods:

Analysis of basal and pentagastrin-stimulated acid, pepsin, pepsinogen group A, and gastrin secretion.
Measurement of prostaglandin levels, neutral glycoproteins, and N-acetylneuraminic acid (NANA) in gastric mucosa.
Review of published data on H2 blocker treatment for GU in elderly patients.

Main Results:

Gastric secretion patterns (acid, pepsin, pepsinogen A, gastrin) did not significantly change with age in GU patients.
Elderly GU patients exhibited higher concentrations of neutral glycoproteins and NANA compared to younger adults.
H2 blockers (famotidine, ranitidine, nizatidine) showed high healing rates for acute GU (67.6%–96.0%) and low relapse rates for chronic GU (8.29%–34.4%) in the elderly.

Conclusions:

Age does not significantly alter gastric secretion in GU patients, though mucosal barrier components like glycoproteins and NANA may increase in the elderly.
Further research is needed on factors like H. pylori, motility, hormones, and psychological aspects in elderly GU patients.
H2 blockers are effective for treating acute GU and maintaining remission in elderly patients.

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