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Updated: Aug 21, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Chronic allograft rejection: an update
1Transplantation Laboratory, University of Helsinki, Finland.
Abstract:
The etiology of chronic rejection is most probably multifactorial. The common feature in all organ allografts undergoing chronic rejection is persistent perivascular inflammation and a concentric generalized arteriosclerosis affecting all first and second order intramural arteries. A hypothesis is presented that low-grade damage to endothelium induces the secretion of growth factors which, in turn, are responsible for smooth muscle cell replication and their influx into intima.
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