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Increased secretion of latent elastase activity following contact between human skin fibroblasts and elastin derived
J M Landeau1, B Pellat, W Hornebeck
1Biochemistry Department, Faculty of Dental Surgery, University René Descartes Paris V, Montrouge, France.
Cell Biology International
|February 1, 1994
Abstract:
Elastin-derived peptides were previously shown to influence human skin fibroblasts (HSF) chemotaxis and proliferation (Ghuysen et al., 1992). We report here that culturing HSF on kappa-elastin (kappa E) but not onto fibronectin (FN) enhanced the secretion of latent elastinolytic activity. The proteinase involved was identified as the 72 kDa gelatinase A. Moreover, HSF-kappa E as well as HSF-FN interactions modulated the secretions of Il1 induced expressions of elastinolytic activities.