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Effect of pentoxifylline, a multidrug resistance reversal agent, on haemopoietic stem cell homing
R P Gude1, M P Chitnis, S G Rao
1Chemotherapy and Stem Cell Biology Division, Cancer Research Institute, Parel, Bombay, India.
Cell Biology International
|February 1, 1994
Abstract:
This paper investigates the mechanism of mouse haemopoietic stem cell homing into the cytoskeleton depolymerizing agent Pentoxifylline was used, and shown to inhibit stem cell homing. The inhibition was reversible after 6 hours. The results obtained suggest that the haemopoietic stem cell homing receptor is anchored to cytoskeletal support intracellularly.