Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequential method of estimating the LD50 using a modified up-and-down rule

H Jung1, S C Choi

  • 1Department of Biostatistics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0032.

Journal of Biopharmaceutical Statistics
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the relative prompt production rate of <i>χ</i><sub>c2</sub> and <i>χ</i><sub>c1</sub> in pp collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Charmonium and <i>e</i><sup>+</sup><i>e</i><sup>-</sup> pair photoproduction at mid-rapidity in ultra-peripheral Pb-Pb collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Energy dependence of the transverse momentum distributions of charged particles in pp collisions measured by ALICE.

The European physical journal. C, Particles and fields·2015
Same author

Jet and underlying event properties as a function of charged-particle multiplicity in proton-proton collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Measurement of the sum of WW and WZ production with W+dijet events in pp collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Search for supersymmetry in pp collisions at [Formula: see text] TeV in events with a single lepton, jets, and missing transverse momentum.

The European physical journal. C, Particles and fields·2015

The modified up-and-down method offers improved LD50 estimation accuracy compared to the original method, especially with chi-square distributions. This toxicological method enhances precision in determining lethal dose 50%.

Area of Science:

  • Toxicology
  • Biostatistics
  • Statistical Methods

Background:

  • Accurate estimation of the lethal dose 50% (LD50) is crucial in toxicology.
  • Traditional methods for LD50 determination have limitations in efficiency and precision.
  • The up-and-down method and its variations are commonly employed for LD50 estimation.

Purpose of the Study:

  • To compare the performance of the original up-and-down method with a modified version, Robbins-Monro, and Spearman-Kärber methods.
  • To evaluate different experimental designs for the modified up-and-down approach.
  • To assess the impact of various tolerance distributions (standard normal and chi-square) on LD50 estimation.

Main Methods:

  • Comparative analysis of statistical methods for LD50 point estimation and confidence intervals.

Related Experiment Videos

  • Investigation of three modified up-and-down experimental designs.
  • Utilizing standard normal and chi-square distributions as tolerance distributions in simulations.

    • Main Results:

    • The modified up-and-down method showed a lower mean squared error than the original method under a normal tolerance distribution.
    • For chi-square distributions, the modified method demonstrated significantly better performance when the test space was wide and the initial dose was far from the LD50.
    • The choice of tolerance distribution and experimental design impacts the accuracy of LD50 estimation.

    Conclusions:

    • The modified up-and-down method is a more efficient and accurate approach for LD50 estimation compared to the original method.
    • The effectiveness of the modified method is particularly pronounced with chi-square tolerance distributions and specific experimental conditions.
    • Simulation results support the utility of the modified up-and-down method in toxicological studies.