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Trisomy 6 as the sole chromosome abnormality in myeloid disorders
P Jonveaux1, P Fenaux, R Berger
1Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Cancer Genetics and Cytogenetics
|June 1, 1994
Abstract:
Trisomy 6 was the sole chromosomal abnormality detected in two patients with myeloid disorders in relapse. One had a refractory anemia with excess of blasts and the other acute myeloblastic leukemia. Simple trisomy 6 has been reported in patients with myeloid disorders, marrow hypoplasia, acute myeloid leukemia, and "preleukemia." The prognostic significance of this nonrandom chromosomal abnormality is discussed.