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[Imaging in atherosclerosis: scintigraphy techniques]

C Greco1, F Scopinaro, A Centi Colella

  • 1II Cattedra di Cardiologia, Università degli Studi La Sapienza, Roma.

Cardiologia (Rome, Italy)
|December 1, 1993
PubMed
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A new antibody (TRF1) shows high affinity for atherosclerotic plaques, offering a potential tool for noninvasive detection. This antibody targets human fragment D-dimer of cross-linked fibrin, aiding in diagnosing atherosclerosis.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomedical Imaging

Background:

  • Noninvasive detection of atherosclerotic plaques is crucial for clinical management.
  • Existing methods for thrombus imaging and plaque detection have limitations.

Purpose of the Study:

  • To evaluate the affinity of a novel F(ab')2 monoclonal antibody (TRF1) for atherosclerotic plaques.
  • To assess TRF1's potential as a diagnostic marker for atherosclerosis.

Main Methods:

  • Radioimmunoassay using 125I-labeled TRF1 and an aspecific antibody.
  • Direct binding tests on human carotid, femoral, and internal mammary artery segments.
  • Analysis of binding to atherosclerotic plaques, fatty streaks, and normal endothelium.

Main Results:

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  • TRF1 demonstrated significantly higher binding to atherosclerotic plaques (26.0%) compared to normal endothelium (1.9%) and fatty streaks (9.23%).
  • No significant binding difference was observed with the aspecific antibody.
  • Binding was statistically significant (p < 0.001).

Conclusions:

  • The TRF1 antibody exhibits specific affinity for atherosclerotic plaques.
  • TRF1 shows promise as a noninvasive imaging agent for detecting atherosclerosis.